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Can I read SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy on EtoBox?
SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy by Pooya Farhangnia; Shamim Mollazadeh Ghomi; Shabnam Mollazadehghomi; Hamid Nickho; Mahzad Akbarpour; Ali-Akbar Delbandi is a Immunology and Microbiology article available to read on EtoBox.
What is SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy about?
The signaling lymphocytic activation molecule (SLAM) family receptors were discovered in immune cells for the first time. The SLAM-family receptors are a significant player in cytotoxicity, humoral immune responses, autoimmune diseases, lymphocyte development, cell survival, and cell adhesion. There is growing evidence that SLAM-family receptors have been involved in cancer progression and heralded as a novel immune checkpoint on T cells. Previous studies have reported the role of SLAMs in tumor immunity in various cancers, including chronic lymphocytic leukemia, lymphoma, multiple myeloma, acute myeloid leukemia, hepatocellular carcinoma, head and neck squamous cell carcinoma, pancreas, lung, and melanoma. Evidence has deciphered that the SLAM-family receptors may be targeted for cancer immunotherapy. However, our understanding in this regard is not complete. This review will discuss the role of SLAM-family receptors in cancer immunotherapy. It will also provide an update on recent advances in SLAM-based targeted immunotherapies.
Who reads SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Pooya Farhangnia; Shamim Mollazadeh Ghomi; Shabnam Mollazadehghomi; Hamid Nickho; Mahzad Akbarpour; Ali-Akbar Delbandi
- Publisher
- Frontiers Media SA
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)