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Can I read Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis on EtoBox?
Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis by Ali Al‐Kaabi; Rachel S van der Post; Jonathan Huising; Camiel Rosman; Iris D Nagtegaal; Peter D Siersema is a Medicine article available to read on EtoBox.
What is Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis about?
## Background Despite modern imaging modalities, staging of clinically staged T2N0M0 (cT2N0M0) oesophageal cancer is suboptimal, often leading to overtreatment. Endoscopic resection – the first-line therapy for early localised tumours – could be used to improve staging and to attain predictors of nodal upstaging enabling more stage-guided treatment decisions. ## Objective A systematic literature review and a meta-analysis were conducted to assess the prevalence and the pathological risk factors of lymph node metastases in cT2N0M0 oesophageal cancer. ## Methods Databases of PUBMED, EMBASE and Cochrane were searched for literature. The primary outcome was lymph node metastases determined after primary surgical resection. ## Results Nine studies with a total of 1650 cT2N0M0 patients were included. The prevalence of lymph node metastases was 43% (95% confidence interval: 35–50%) with heterogeneity being high across studies (__I__^2^ = 0.86, __p__ < 0.001). Factors potentially attainable by endoscopic resection and having a significant association with lymph node metastases were invasion depth, differentiation grade, tumour size, depth of invasion in the muscularis propria and lymphovas
Who reads Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ali Al‐Kaabi; Rachel S van der Post; Jonathan Huising; Camiel Rosman; Iris D Nagtegaal; Peter D Siersema
- Publisher
- Wiley
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)