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Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence by Terteel Elawad; Georgia Scott; Jeffrey N. Bone; Helen Elwell; Cristina Escalona Lopez; Veronique Filippi; Marcus Green; Asma Khalil; Mai‐Lei W. Kinshella; Hiten D. Mistry; Kelly Pickerill; Reshma Shanmugam; Joel Singer; Rosemarie Townsend; Eleni Z. Tsigas; Marianne Vidler; Marie‐Laure Volvert; Peter von Dadelszen; Laura A. Magee; the PRECISE Network is a Medicine article available to read on EtoBox.
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## Abstract ## Objective To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention. ## Design Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021. ## Setting Published studies and CPGs. ## Population Pregnant women. ## Methods We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review. ## Main outcome measure Pre‐eclampsia. ## Results Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually ‘probable’ (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The ‘major’ and ‘moderate’ risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten ‘major’ risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity (‘moderat
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- Author
- Terteel Elawad; Georgia Scott; Jeffrey N. Bone; Helen Elwell; Cristina Escalona Lopez; Veronique Filippi; Marcus Green; Asma Khalil; Mai‐Lei W. Kinshella; Hiten D. Mistry; Kelly Pickerill; Reshma Shanmugam; Joel Singer; Rosemarie Townsend; Eleni Z. Tsigas; Marianne Vidler; Marie‐Laure Volvert; Peter von Dadelszen; Laura A. Magee; the PRECISE Network
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)