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A Mathematical Model for Cell Cycle Control: Graded Response or Quantized Response by Guoyu Wu; Huiyu Xiu; Haiying Luo; Yu Ding; Yuchao Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Mathematical Model for Cell Cycle Control: Graded Response or Quantized Response about?

Cell cycle is an important and complex biological system. A lot of efforts have been put in understanding cell cycle arrest for its vital role in clinical therapies. The cell-cycle-arrest outcomes upon stimulation are complicated. The response could be stringent or relaxed, and graded or quantized. A model fully addressing various cell-cycle-arrest outcomes is to be developed. Here, we developed a mathematical model of cell cycle control incorporating distinct characteristics of various cell-cycle-arrest outcomes. The model can simulate two typical properties of cell cycle arrest, quantized and graded. We also characterized the inheritable quiescence and refractory state, which were crucial in long-term response of the population. Then, we monitored cells respond to multiple stimulations, and the results indicated that cells responded to stimulations with small interval did not induce significantly sustained cell cycle arrest as the existence of refractory state. Our work will benefit fundamental research and make efforts to predicting outcomes of clinical therapeutics.

Who reads A Mathematical Model for Cell Cycle Control: Graded Response or Quantized Response?

Author

Guoyu Wu; Huiyu Xiu; Haiying Luo; Yu Ding; Yuchao Li

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)