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Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta‐analysis by Paschalis Karakasis; Dimitrios Patoulias; Nikolaos Fragakis; Aleksandra Klisic; Manfredi Rizzo is a Medicine article available to read on EtoBox.
What is Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta‐analysis about?
## Abstract ## Aim The present systematic review aimed to summarize the available evidence from published randomized controlled trials (RCTs) regarding the effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus. ## Materials and Methods Medline (via PubMed), Cochrane Library and Scopus were searched until 20 October 2023. Double‐independent study selection, data extraction and quality assessment were performed. Evidence was pooled with a three‐level mixed‐effects meta‐analysis. ## Results In total, 9533 participants from eight RCTs were analysed. All RCTs had a low risk of bias, according to the Cochrane Collaboration tool (RoB2). Tirzepatide was associated with a significantly greater reduction in urine albumin‐to‐creatinine ratio compared with controls [mean difference (MD) −26.9%; 95% confidence interval (CI) (−34.76, −19.04); __p__ < .001; level of evidence (LoE) moderate]. This effect remained significant in participants with baseline urine albumin‐to‐creatinine ratio ≥30 mg/g [MD −41.42%; 95% CI (−54.38, −28.45); __p__ < .001; LoE moderate]. Based on subgroup analysis, the comparative effect of tirzepatide was significant agai
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- Author
- Paschalis Karakasis; Dimitrios Patoulias; Nikolaos Fragakis; Aleksandra Klisic; Manfredi Rizzo
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)