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Model-based Source Localization of Extracellular Action Potentials by Zoltán Somogyvári; László Zalányi; István Ulbert; Péter Érdi is a Neuroscience article available to read on EtoBox.

What is Model-based Source Localization of Extracellular Action Potentials about?

A new model-based analysis method was set up for revealing information encrypted in extracellular spatial potential patterns of neocortical action potentials. Spikes were measured by extracellular linear multiple microelectrode in vivo cat's primary auditory cortex and were analyzed based on current source density (CSD) distribution models. Validity of the monopole and other point source approximations were tested on the measured potential patterns by numerical fitting. We have found, that point source models could not provide accurate description of the measured patterns. We introduced a new model of the CSD distribution on a spiking cell, called counter-current model (CCM). This new model was shown to provide better description of the spatial current distribution of the cell during the initial negative deflection of the extracellular action potential, from the onset of the spike to the negative peak. The new model was tested on simulated extracellular potentials. We proved numerically, that all the parameters of the model could be determined accurately based on measurements. Thus, fitting of the CCM allowed extraction of these parameters from the measurements. Due to model fittin

Who reads Model-based Source Localization of Extracellular Action Potentials?

Author

Zoltán Somogyvári; László Zalányi; István Ulbert; Péter Érdi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-0270)

Published

2005

Language

EN

Field

Neuroscience (Life Sciences)