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Characterization of Protein-Ligand Interactions by SSNMR by Pronoy Majumder is a document available to read on EtoBox.
This document describes a novel high-resolution solid-state NMR spectroscopy method for characterizing protein-ligand interactions, specifically using the anti-apoptotic protein Bcl-xL. The technique allows for site-specific resonance assignment and monitoring of chemical shift changes upon ligand binding, which can distinguish direct contacts from conformational changes. The results indicate that solid-state NMR can effectively study ligand binding in proteins that are not suitable for solution NMR analysi
- Author
- Pronoy Majumder
- Language
- EN