Skip to content

Opening book details…

Can I read Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation on EtoBox?

Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation by Stavsky, Alexandra (author);Stoler, Ohad (author);Kostic, Marko (author);Katoshevsky, Tomer (author);Assali, Essam A. (author);Savic, Ivana (author);Amitai, Yael (author);Prokisch, Holger (author);Leiz, Steffen (author);Daumer-Haas, Cornelia (author);Fleidervish, Ilya (author);Perocchi, Fabiana (author);Gitler, Daniel (author);Sekler, Israel (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation about?

Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main source of cellular energy, serve as calcium signaling hubs. Mitochondrial calcium transients are primarily determined by the balance between calcium influx, mediated by the mitochondrial calcium uniporter (MCU), and calcium efflux through the sodium/lithium/calcium exchanger (NCLX). We identified a human recessive missense __SLC8B1__ variant that impairs NCLX activity and is associated with severe mental retardation. On this basis, we examined the effect of deleting NCLX in mice on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity. Neuronal mitochondria exhibited basal calcium overload, membrane depolarization, and a reduction in the amplitude and rate of calcium influx and efflux. We observed smaller cytoplasmic calcium transients in the presynaptic terminals of NCLX-KO neurons, leading to a lower probability of release and weaker transmission. In agreement, synaptic facilitation in NCLX-KO hippocampal slice

Who reads Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Stavsky, Alexandra (author);Stoler, Ohad (author);Kostic, Marko (author);Katoshevsky, Tomer (author);Assali, Essam A. (author);Savic, Ivana (author);Amitai, Yael (author);Prokisch, Holger (author);Leiz, Steffen (author);Daumer-Haas, Cornelia (author);Fleidervish, Ilya (author);Perocchi, Fabiana (author);Gitler, Daniel (author);Sekler, Israel (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

More by Stavsky, Alexandra (author);Stoler, Ohad (author);Kostic, Marko (author);Katoshevsky, Tomer (author);Assali, Essam A. (author);Savic, Ivana (author);Amitai, Yael (author);Prokisch, Holger (author);Leiz, Steffen (author);Daumer-Haas, Cornelia (author);Fleidervish, Ilya (author);Perocchi, Fabiana (author);Gitler, Daniel (author);Sekler, Israel (author)

Browse all works by Stavsky, Alexandra (author);Stoler, Ohad (author);Kostic, Marko (author);Katoshevsky, Tomer (author);Assali, Essam A. (author);Savic, Ivana (author);Amitai, Yael (author);Prokisch, Holger (author);Leiz, Steffen (author);Daumer-Haas, Cornelia (author);Fleidervish, Ilya (author);Perocchi, Fabiana (author);Gitler, Daniel (author);Sekler, Israel (author)