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Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis by Irene Müller; Thomas Vogl; Uwe Kühl; Alexander Krannich; Aron Banks; Tobias Trippel; Michel Noutsias; Alan S. Maisel; Sophie van Linthout; Carsten Tschöpe is a Medicine article available to read on EtoBox.

What is Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis about?

## Abstract ## Aims The alarmin S100A8/S100A9 (S100A8/A9) is released by activated monocytes/macrophages and neutrophils in the setting lymphocytic myocarditis (MC). We recently demonstrated its therapeutic potential in experimental acute MC. Now, we investigated the diagnostic relevance of S100A8/A9 serum levels in patients with suspected acute and chronic MC and in patients with heart failure without cardiac inflammation. ## Methods and Results Serum S100A8/A9 levels were analysed in patients with a recent onset of MC [≤ 30 days, __n__ = 32; ejection fraction (EF): 45.4 ± 12.9%], dilated cardiomyopathy patients with inflammation (__n__ = 112; EF: 29.0 ± 11.4%), or without inflammation (__n__ = 58; EF: 26.6 ± 9.3%), and controls (__n__ = 25; EF: 68.5 ± 4.6%), by using specific ELISAs. Blood samples were collected at Time Point 1 (T1), where also endomyocardial biopsies (EMBs) were withdrawn. Patients with a recent onset of MC showed a 4.6‐fold increase in serum S100A8/A9 levels vs. controls (MC: 1948 ± 1670 ng/mL vs. controls: 426 ± 307 ng/mL; __P__ < 0.0001). Serum S100A8/A9 correlated with the disease activity, represented by EMB‐derived counts of inflammatory cells (CD3: __r__

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Author

Irene Müller; Thomas Vogl; Uwe Kühl; Alexander Krannich; Aron Banks; Tobias Trippel; Michel Noutsias; Alan S. Maisel; Sophie van Linthout; Carsten Tschöpe

Publisher

Wiley

Published

2020

Language

EN

Field

Medicine (Health Sciences)