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Can I read Iron-Catalyzed Intermolecular Amination of Benzylic C(sp^3^)–H Bonds on EtoBox?
Iron-Catalyzed Intermolecular Amination of Benzylic C(sp^3^)–H Bonds by Hillol Khatua; Subrata Das; Sima Patra; Sandip Kumar Das; Satyajit Roy; Buddhadeb Chattopadhyay is a Chemistry article available to read on EtoBox.
What is Iron-Catalyzed Intermolecular Amination of Benzylic C(sp^3^)–H Bonds about?
A catalytic system for intermolecular benzylic C(sp 3 )−H amination is developed utilizing 1,2,3,4-tetrazole as a nitrene precursor via iron catalysis. This method enables direct installation of 2-aminopyridine into the benzylic and heterobenzylic position. The method selectively aminates 2°benzylic C(sp 3 )−H bond over the 3°and 1°benzylic C(sp 3 )−H bonds. Experimental studies reveal that the C(sp 3 )−H amination undergoes via the formation of a benzylic radical intermediate. This study reports the discovery of new method for 2-pyridine substituted benzylamine synthesis using inexpensive, biocompatible base metal catalysis that should have wide application in the context of medicinal chemistry and drug discovery.
Who reads Iron-Catalyzed Intermolecular Amination of Benzylic C(sp^3^)–H Bonds?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Hillol Khatua; Subrata Das; Sima Patra; Sandip Kumar Das; Satyajit Roy; Buddhadeb Chattopadhyay
- Publisher
- American Chemical Society (ACS)
- Published
- 2022
- Language
- EN
- Field
- Chemistry (Physical Sciences)