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Sacubitril/valsartan Ameliorates Renal Tubulointerstitial Injury Through Increasing Renal Plasma Flow in a Mouse Model of Type 2 Diabetes with Aldosterone Excess by Haruomi Nishio; Akira Ishii; Hiroyuki Yamada; Keita P Mori; Yukiko Kato; Shoko Ohno; Takaya Handa; Sayaka Sugioka; Takuya Ishimura; Akie Ikushima; Yui Inoue; Naoto Minamino; Masashi Mukoyama; Motoko Yanagita; Hideki Yokoi is a Medicine article available to read on EtoBox.
What is Sacubitril/valsartan Ameliorates Renal Tubulointerstitial Injury Through Increasing Renal Plasma Flow in a Mouse Model of Type 2 Diabetes with Aldosterone Excess about?
Abstract Background Aldosterone has been assumed to be one of aggravating factors in diabetic kidney disease (DKD). Natriuretic peptides/guanylyl cyclase-A/cGMP signalling has been shown to ameliorate aldosterone-induced renal injury in mice. Sacubitril/valsartan (SAC/VAL) is used clinically for chronic heart failure and hypertension, in part by augmenting natriuretic peptide bioavailability. The effects of SAC/VAL on renal pathophysiology including in DKD, however, have remained unclarified yet. Methods Eight-week-old male db/db mice fed on a high-salt diet (HSD) were treated with vehicle or aldosterone (0.2 μg/kg/min), and divided into 4 groups: HSD control, ALDO (aldosterone), ALDO + VAL (valsartan), and ALDO + SAC/VAL group. After 4 weeks, they were analyzed for plasma atrial natriuretic peptide (ANP) levels, renal histology, and haemodynamic parameters including glomerular filtration rate (GFR) by FITC-inulin and renal plasma flow (RPF) by para-amino hippuric acid. Results The ALDO + SAC/VAL group showed significantly increased plasma ANP concentration and creatinine clearance, and decreased tubulointerstitial fibrosis and neutrophil gelatinase-associated lipocalin expression
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- Author
- Haruomi Nishio; Akira Ishii; Hiroyuki Yamada; Keita P Mori; Yukiko Kato; Shoko Ohno; Takaya Handa; Sayaka Sugioka; Takuya Ishimura; Akie Ikushima; Yui Inoue; Naoto Minamino; Masashi Mukoyama; Motoko Yanagita; Hideki Yokoi
- Publisher
- Oxford University Press (OUP)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)