Can I read Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia on EtoBox?

Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia by Clinton O. Onyango; Qiuying Cheng; Elly O. Munde; Evans Raballah; Samuel B. Anyona; Benjamin H. McMahon; Christophe G. Lambert; Patrick O. Onyango; Kristan A. Schneider; Douglas J. Perkins; Collins Ouma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia about?

## Background __Plasmodium falciparum__ malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) G and rs11575837:C > T) and their haplotypes. The prospective observational study was conducted over a 36 mos. follow-up period in a cohort of children (__n__ = 1,515, aged 1.9–40 mos.) residing in a holoendemic __P. falciparum__ transmission region, Siaya, Kenya. ## Results Poisson regression modeling, controlling for anemia-promoting covariates, revealed a significantly increased risk of malaria in carriers of the homozygous mutant allele genotype (TT) for rs11575837 after multiple test correction [Incidence rate ratio (IRR) = 1.540, 95% CI = 1.114–2.129, __P__ = 0.009]. Increased risk of SMA was observed for rs2736191 in children who inherited the CG genotype (IRR = 1.269, 95% CI = 1.009–1.597, __P__ = 0.041) and in the additive model (presence of 1 or 2 copies) (IRR = 1.198, 95% CI = 1.030–1.393, __P__ = 0.019), but was not significant after multiple test correction. Modeling of the haplotypes revealed that the CC haplotype had a significant additive effect for protection against SMA (i.e., redu

Who reads Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia?

Author

Clinton O. Onyango; Qiuying Cheng; Elly O. Munde; Evans Raballah; Samuel B. Anyona; Benjamin H. McMahon; Christophe G. Lambert; Patrick O. Onyango; Kristan A. Schneider; Douglas J. Perkins; Collins Ouma

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)