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Creatinine: From physiology to clinical application by Kianoush Kashani; Mitchell H. Rosner; Marlies Ostermann is a Medicine article available to read on EtoBox.

What is Creatinine: From physiology to clinical application about?

Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided. Take-home points Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging and critically important.While serum creatinine is the most widely used functional biomarker of the kidney, it is associated with substantial shortcomings. Estimation of kidney function using serum creatinine should be made with considerati

Who reads Creatinine: From physiology to clinical application?

Author

Kianoush Kashani; Mitchell H. Rosner; Marlies Ostermann

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Medicine (Health Sciences)