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Lack of adaptation to human tetherin in HIV-1 Group O and P by Su Jung Yang; Lisa A Lopez; Colin M Exline; Kevin G Haworth; Paula M Cannon is a Immunology and Microbiology article available to read on EtoBox.

What is Lack of adaptation to human tetherin in HIV-1 Group O and P about?

## Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite the same genomic organization, only the group M viruses are responsible for the world-wide pandemic of AIDS, suggesting better adaptation to human hosts. Previously, it has been reported that the group M Vpu protein is capable of both down-modulating CD4 and counteracting BST-2/tetherin restriction, while the group O Vpu cannot antagonize tetherin. This led us to investigate if group O, and the related group P viruses, possess functional anti-tetherin activities in Vpu or another viral protein, and to further map the residues required for group M Vpu to counteract human tetherin. ## Results We found a lack of activity against human tetherin for both the Vpu and Nef proteins from group O and P viruses. Furthermore, we found no evidence of anti-human tetherin activity in a fully infectious group O proviral clone, ruling out the possibility of an alternative anti-tetherin factor in this virus. Interestingly, an activity against primate tetherins was retained in the Nef proteins from both a group O and a group P virus. By making chimeras between a functional group M and non-functional group O

Who reads Lack of adaptation to human tetherin in HIV-1 Group O and P?

Author

Su Jung Yang; Lisa A Lopez; Colin M Exline; Kevin G Haworth; Paula M Cannon

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2004-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1742-4690)

Published

2011

Language

EN

Field

Immunology and Microbiology (Life Sciences)