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The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality by Nicole Prüfer; Burkhard Kleuser; Markus van der Giet is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL’s anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL’s protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may have impact on HDL’s biological functions, including cholesterol efflux capacity, antioxidative and anti-inflammatory activities. This review

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Author

Nicole Prüfer; Burkhard Kleuser; Markus van der Giet

Publisher

Walter de Gruyter GmbH

Published

2014

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)