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What is Complications of HIV/AIDS and other secondary immunodeficiencies about?
Underlying immunodeficiency is suspected when patients present with more frequent, more severe, recurrent and more prolonged infections that often respond poorly to therapy. Prominent among such immunodeficiencies is the acquired immunodeficiency syndrome (AIDS). The gastrointestinal tract plays a fundamental role in the pathogenesis of AIDS and is a focus of AIDS-related complications (Table 118.1). Infectious processes comprise the majority of these complications and are responsible for relentless morbidity and, in some cases, mortality. Limiting the degree of immunosuppression with effective antiretroviral therapy for human immunodeficiency virus-1 (HIV-1), the causative agent of AIDS, is often a mainstay of the effective prevention and therapy of AIDS and its complications. This chapter focuses on the intestinal infections and key gastrointestinal syndromes associated with AIDS and other secondary immunodeficiency states. ## Role of the gastrointestinal mucosa in HIV-1 pathogenesis All HIV-1 infections, excluding those acquired through intravenous drug use, transfusions and parenterally, are transmitted across mucosal surfaces [1]. In addition to their role in HIV-1 transmissio
- Author
- Phillip D. Smith; Edward N. Janoff
- Publisher
- John Wiley & Sons Inc.; Wiley-Interscience; Wiley-Blackwell
- Published
- 2015
- Language
- EN
- ISBN
- 9781118512159
- Subjects
- Medical, Medicine
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