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Differential role of the nitric oxide pathway on Δ^9^‐THC‐induced central nervous system effects in the mouse by Shahnaz Christina Azad; Giovanni Marsicano; Irina Eberlein; Jörg Putzke; Walter Zieglgänsberger; Rainer Spanagel; Beat Lutz is a Neuroscience article available to read on EtoBox.
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## Abstract This study investigated whether the nitric oxide pathway was involved in the central effects of Δ^9^‐tetrahydrocannabinol (Δ^9^‐THC), the major psychoactive constituent of __cannabis sativa__. Body temperature, nociception and locomotion were measured in neuronal nitric oxide synthase (nNOS) knock‐out (KO) mice and wild‐type (WT) controls after intraperitoneal application of Δ^9^‐THC. These Δ^9^‐THC‐induced effects are known to be mediated through the brain‐type cannabinoid receptor 1 (CB1). Therefore, __in situ__ hybridization (ISH) experiments were performed in the adult murine brain to determine possible changes in CB1 mRNA levels in nNOS‐KO, compared with WT mice, and to reveal brain areas where CB1 and nNOS were coexpressed in the same neurons. We found that an intraperitoneal injection of 10 mg/kg Δ^9^‐THC led to the same increase in the hot plate latencies in both genotypes, suggesting that Δ^9^‐THC‐mediated antinociception does not involve nNOS. In contrast, a significant Δ^9^‐THC‐induced decrease of body temperature and locomotor activity was only observed in WT, but not in nNOS‐KO mice. ISH revealed significantly lower levels of CB1 mRNA in the ventromedial hy
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- Author
- Shahnaz Christina Azad; Giovanni Marsicano; Irina Eberlein; Jörg Putzke; Walter Zieglgänsberger; Rainer Spanagel; Beat Lutz
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)