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Can I read Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels on EtoBox?
Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels by Hui Liu; Zhiwei Deng; Tianhao Li; Jiaqi Bu; De Wang; Jiahui Wang; Meng Liu; Jiacheng Li; Yanjing Yang; Shian Zhong is a Materials Science article available to read on EtoBox.
What is Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels about?
Injectable hydrogels are potential local drug delivery systems since they contain plenty of water and soft like biological tissues. Such hydrogels could be injected directly into the tumor site where the drug is released under the tumor microenvironment. However, drug loaded hydrogels for cancer treatment based on lipoic acid (natural small molecule) have not been exploited. Here, a novel poly(lipoic acid)-poly(ethylene glycol) (PEG-PTA) hydrogels were prepared through a two-step reaction. The hydrogels contained disulfide bonds, so they could be degraded via the thiol exchange reaction with the abundant GSH in the tumor microenvironment, and subsequently release the drug. The results in vitro and at cellular level showed that the hydrogels were degraded and released the drugs only in the presence of GSH. Therefore, the injectable GSH-responsive hydrogels are promising to be served as an intelligent drug delivery system for cancer treatment.
Who reads Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Hui Liu; Zhiwei Deng; Tianhao Li; Jiaqi Bu; De Wang; Jiahui Wang; Meng Liu; Jiacheng Li; Yanjing Yang; Shian Zhong
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)