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The study investigates the neuroprotective effects of C8-B4 microglia transformed by repetitive low-dose lipopolysaccharide (LPS) against streptozotocin (STZ)-induced neuronal cell death. Results indicate that LPSx3-microglia promote the secretion of neurotrophin-4/5 (NT-4/5), which is involved in preventing neuronal damage. The findings suggest that transforming microglia into a neuroprotective state could be a potential strategy for addressing diabetes-associated neuronal dysfunction.
- Author
- Maftuna Shamshiddinova
- Language
- EN