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Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5 by Andreas H. Zisch; William B. Stallcup; Lisa D. Chong; Kimberlee Dahlin-Huppe; Joannes Voshol; Melitta Schachner; Elena B. Pasquale is a Neuroscience article available to read on EtoBox.
What is Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5 about?
The L1 family comprises transmembrane cell adhesion molecules of the immunoglobulin superfamily that play an important role in neuronal migration and axon outgrowth, fasciculation, and myelination. Consistent with a crucial role in developmental processes, mutations in L1 cause severe brain malformations. Although L1 activates intracellular signaling pathways, little is known about the membrane proximal events of L1 signaling. The cytoplasmic domains of L1 family proteins contain several conserved tyrosine residues that are potential targets for receptor tyrosine kinases. Here, we report that the L1 family protein Ng-CAM is phosphorylated on tyrosine in embryonic day 13 chicken retina. This is the first demonstration of in vivo tyrosine phosphorylation of an L1-like molecule. Because chicken embryo kinase 5 (Cek5) is a receptor tyrosine kinase expressed in neuronal processes and activated in the chicken embryonic retina, we have analyzed the possible role of Cek5 in L1 phosphorylation. The rat glioblastoma cell line B28 was stably transfected with human L1. Additional transient transfection with Cek5 cDNA led to expression of Cek5 in its tyrosine-phosphorylated, activated form. Bio
Who reads Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Andreas H. Zisch; William B. Stallcup; Lisa D. Chong; Kimberlee Dahlin-Huppe; Joannes Voshol; Melitta Schachner; Elena B. Pasquale
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)