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Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples by Nimgaonkar, V. L.; Sanders, A. R.; Ganguli, R.; Zhang, X. R.; Brar, J.; Hogge, W.; Fann, W. E.; Patel, P. I.; Chakravarti, A. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples about?
Using a case-control design, an association of schizophrenia with the dopamine D3 receptor gene (D3RG) locus was investigated. Initial analysis of pooled results from published studies revealed a significant excess of individuals homozygous for either allele among the patients. The association was next tested in two cohorts ascertained independently at Pittsburgh, Pennsylvania and at Houston, Texas. The Pittsburgh sample was comprised of patients with schizophrenia (DSM-111-R) (n = 130). The controls belonged to two groups: adults screened for the absence of substance abuse or major psychiatric illness (n = 128), and neonates (n = 160). Multivariate analysis suggested an association with allele 1 of the biallelic D3RG polymorphism in comparison with the adult, but not the neonatal, controls. The association was most marked among Caucasian patients with a family history of schizophrenia (odds ratio 13.69, confidence intervals 1.80,104.30). Survival analysis suggested an earlier age of onset among male patients homozygous for allele 2. The Houston cohort included Caucasian patients with schizophrenia or schizoaffective disorder (DSM-111-R criteria, n = 50), and normal controls matche
Who reads Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nimgaonkar, V. L.; Sanders, A. R.; Ganguli, R.; Zhang, X. R.; Brar, J.; Hogge, W.; Fann, W. E.; Patel, P. I.; Chakravarti, A.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 1996
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)