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The Role of Matrix Metalloproteinases in Infectious Corneal Ulcers by Celia García-López; Marina Rodríguez-Calvo-de-Mora; Davide Borroni; José-María Sánchez-González; Vito Romano; Carlos Rocha-de-Lossada is a Medicine article available to read on EtoBox.

What is The Role of Matrix Metalloproteinases in Infectious Corneal Ulcers about?

During infectious keratitis, the production of collagenolytic and inflammatory substances, along with increased corneal metalloproteinase (MMP) activity, induce the degradation of corneal collagen and may cause post keratitis complications such as opacity, thinning, and corneal perforation. MMPs, especially MMP-2 and MMP-9, are over-expressed in infectious keratitis and sustained over time by inflammatory and non-microbial mechanisms. The high MMP levels are correlated with an excessive corneal destruction in bacterial, herpetic, fungal and acanthamoeba infections. Nonspecific treatments such as tetracyclines, particularly doxycycline, or corticosteroids are used as adjuvants to antimicrobials to alleviate the disproportionate degradation and inflammation of the corneal layers caused by corneal MMPs and to decrease the recruitment and infiltration of inflammatory cells. Specific treatments showing inhibition of specific MMPs (Galardin, ZHAWOC7726), interfering with pro-MMPs activation (EDTA, ascorbic acid) or showing anti-cytokine effect (epigallocatechin-2-gallate, TRAM-34) have been reported. Other treatments show a direct action over corneal collagen structure such as corneal cr

Who reads The Role of Matrix Metalloproteinases in Infectious Corneal Ulcers?

Author

Celia García-López; Marina Rodríguez-Calvo-de-Mora; Davide Borroni; José-María Sánchez-González; Vito Romano; Carlos Rocha-de-Lossada

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)