Can I read Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae on EtoBox?

Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae by Renee M. Fleeman; Luis A. Macias; Jennifer S. Brodbelt; Bryan W. Davies is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae about?

## Significance The capsule of __Klebsiella pneumoniae__ is composed of extracellular polysaccharides that inhibit the activity of host defense peptides and polymyxins. We generated an active antimicrobial peptide from a previously inactive parental peptide and characterized the interactions of these peptides with __K. pneumoniae__ and its capsule. Compared with the inactive parent peptide, we found that our active peptide retained strong binding to capsule but lost structural integrity. These interactions induced capsule aggregation and capsule disruption, a previously undescribed mechanism for promoting antimicrobial activity toward __K. pneumoniae__. This finding may allow further exploitation of this mechanism to destroy the protective capsule that __K. pneumoniae__ uses to resist our immune response and antibiotics.

Who reads Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae?

Author

Renee M. Fleeman; Luis A. Macias; Jennifer S. Brodbelt; Bryan W. Davies

Publisher

National Academy of Sciences; Proceedings of the National Academy of Sciences; Oxford University Press (OUP); Publons; ScienceOpen (ISSN 0027-8424)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)