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Comparative Expression of Endogenous Retrotransposons in Adult Mouse Mammary Gland During Normal Development and Differentiation by Harold L. Asch; Robert Z. Vinci; Jae Y. Chang; Farah Natoli; Daniel L. Stoler; Garth R. Anderson; Bonnie B. Asch is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Amplified expression of the endogenous retrotransposons, intracisternal A particles (IAPs) and murine leukemia virus‐related elements (MLVEs), along with decreased expression of VL30 elements frequently occurs during mouse mammary tumorigenesis. We have now analyzed the expression of these retroelements during the normal developmental and differentiation cycle of the mammary gland as found in virgin, pregnant, lactating, and post‐lactation adult female BALB/c mice. Retrotransposon expression was either unchanged or decreased during the progressive stages of the cycle compared to virgin tissue. Likewise, growth of mammary epithelial cells in primary culture had little or no effect on expression of IAPs, MLVEs and VL30 sequences. Thus, the dramatic changes involving these retrotransposons in many mouse mammary tumors appear unrelated to any normal state.

Who reads Comparative Expression of Endogenous Retrotransposons in Adult Mouse Mammary Gland During Normal Development and Differentiation?

Author

Harold L. Asch; Robert Z. Vinci; Jae Y. Chang; Farah Natoli; Daniel L. Stoler; Garth R. Anderson; Bonnie B. Asch

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1065-6995)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)