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Can I read No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin lociKMorGM: Linkage of Insulin-Dependent Diabetes,KMandGM on EtoBox?
No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin lociKMorGM: Linkage of Insulin-Dependent Diabetes,KMandGM by Dr. L. Leigh Field; Alisa Goldstein; M. Anne Spence; C. E. Anderson; David L. Rimoin; D. C. Rao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin lociKMorGM: Linkage of Insulin-Dependent Diabetes,KMandGM about?
We studied 52 families having more than one member affected with insulindependent diabetes mellitus (IDDM) for linkage of an IDDM-susceptibility locus to the immunoglobulin loci KM and GM. Linkage was analyzed by the LOD score method using single-locus recessive and dominant models of IDDM inheritance, with penetrances of the disease-susceptible genotypes being dependent on age and reaching a maximum of 20% by age 40. We found no evidence for linkage of IDDM to KM or GM. Close linkage (recombination fraction < 5%) was rejected for KM under the recessive model and for GM under both models. These results suggest either that there are no IDDM-susceptibility loci closely linked to KM or GM or that use of a single-locus model of IDDM (which ignores the effects of the susceptibility locus in the HLA region) is inadequate for their detection.
Who reads No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin lociKMorGM: Linkage of Insulin-Dependent Diabetes,KMandGM?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dr. L. Leigh Field; Alisa Goldstein; M. Anne Spence; C. E. Anderson; David L. Rimoin; D. C. Rao
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)
- Published
- 1984
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)