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This study developed a copovidone-based hot-melt extruded formulation of indomethacin to enhance its dissolution and oral bioavailability, addressing its low solubility as a BCS Class II drug. The optimized formulation showed significant improvements in solubility and absorption rates in pharmacokinetic studies, confirming the effectiveness of hot-melt extrusion as a formulation strategy. Stability tests indicated that the amorphous state and dissolution performance were maintained throughout the storage pe

Author

pardeshichandan2002

Language

EN