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The Hemodynamic Power of the Heart Differentiates Normal from Diseased Right Ventricles by Gianni Pedrizzetti; Giorgio Faganello; Elisa Croatto; Andrea Di Lenarda is a Medicine article available to read on EtoBox.

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Cardiac mechanics is primarily described by the pressure-volume relationship. The ventricular pressure-volume loop displays the instantaneous relationship between intraventricular pressure and volume throughout the cardiac cycle; however, it does not consider the shape of the ventricles, their spatiotemporal deformation patterns, and how these balance with the flowing blood. Our study demonstrates that the pressure-volume relationship represents a first level of approximation for the mechanical power of the ventricles, while, at a further level of approximation, the importance of hemodynamic power emerges through the balance between deformation patterns and fluid dynamics. The analysis is preliminarily tested in a healthy subject's right ventricle and two patients. Moreover, patients' geometry was then rescaled to present a normal volumetric profile to verify whether results were affected by volume size or by the spatiotemporal pattern of how that volume profile was achieved. Results show that alterations of hemodynamic power were found in the abnormal ventricles and that they were not directly caused by the ventricular size but by changes in the ability of intraventricular pressur

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Author

Gianni Pedrizzetti; Giorgio Faganello; Elisa Croatto; Andrea Di Lenarda

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)