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Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta by Bernard A. Caplan; Colin J. Schwartz is a Medicine article available to read on EtoBox.

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Focal areas of spontaneous increased aortic endothelial permeability to the protein-binding azo dye Evans Blue in vivo have been further characterized in 8-12 week-old normocholesterolaemic pigs by means of Hautchen preparations with [sH]thymidine autoradiography, together with observations on endothelial cell length, cell area, and surface morphology. Endothelial cell turnover was significantly greater in areas of dye accumulation than in contiguous areas showing no dye accumulation. No differences in turnover between cells derived from white areas in the thoracic arch and abdominal aorta were observed. Control studies indicated that the greater labelling index in blue areas was not due to the presence of Evans Blue dye itself. Although both endothelial cell length and area were not measurably different in blue and white areas, endothelial cells derived from areas of dye accumulation appeared rounder and exhibited a less distinct polarity. This study has shown that as early as 8-12 weeks after birth, focal areas can be identified in the macroscopically normal pig aorta which exhibit an increased endothelial labelling index. The increased [sH]thymidine labelling of endothelial cell

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Author

Bernard A. Caplan; Colin J. Schwartz

Publisher

Elsevier BV

Published

1973

Language

EN

Field

Medicine (Health Sciences)