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A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture by Sylvia Haus; Sara Jabbari; Thomas Millat; Holger Janssen; Ralf-Jörg Fischer; Hubert Bahl; John R King; Olaf Wolkenhauer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture about?
## Background __Clostridium acetobutylicum__ is an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel. For butanol production by __C. acetobutylicum__ to be optimized and exploited on an industrial scale, the effect of pH-induced gene regulation on solvent production by __C. acetobutylicum__ in continuous culture must be understood as fully as possible. ## Results We present an ordinary differential equation model combining the metabolic network governing solvent production with regulation at the genetic level of the enzymes required for this process. Parameterizing the model with experimental data from continuous culture, we demonstrate the influence of pH upon fermentation products: at high pH (pH 5.7) acids are the dominant product while at low pH (pH 4.5) this switches to solvents. Through steady-state analyses of the model we focus our investigations on how alteration in gene expression of __C. acetobutylicum__ could be exploited to increase butanol yield in a continuous culture fermentation. ## Conclusions Incorporating gene regulation into the model of
Who reads A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sylvia Haus; Sara Jabbari; Thomas Millat; Holger Janssen; Ralf-Jörg Fischer; Hubert Bahl; John R King; Olaf Wolkenhauer
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)