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Can I read Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient on EtoBox?
Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient by U. Rüb; C. Schultz; K. Del Tredici; K. Gierga; G. Reifenberger; R. A. I De Vos; C. Seifried; H. Braak; G. Auburger is a Medicine article available to read on EtoBox.
What is Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient about?
Dysfunctions of the somatosensory system are among the clinical signs that characterize a variety of polyglutamine or CAG‐repeat diseases. Deficits within this system may hinder the perception of potential threats, be detrimental to somatomotor functions, and result in uncoordinated movements, ataxia, and falls. Despite the considerable clinical relevance of such deficits, however, no systematic pathoanatomical studies of the central somatosensory system in polyglutamine diseases are currently available. The present paper has two goals: (1) re‐commendation of an economical tissue sampling method and optimized histological processing of this tissue to allow rapid and reliable evaluation of the structural integrity of all known relay stations and interconnecting fibre tracts within this complex system, and (2) the proposal of guidelines for a rapid and detailed pathoanatomical investigative procedure of the human central somatosensory system. In so doing, we draw on the current state of neuroanatomic research and apply the methods and guidelines proposed here to a 25‐year‐old female patient with spinocerebellar ataxia type 2 (SCA2). The use of 100 μm serial sections through the SCA2
Who reads Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- U. Rüb; C. Schultz; K. Del Tredici; K. Gierga; G. Reifenberger; R. A. I De Vos; C. Seifried; H. Braak; G. Auburger
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1846)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)