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Can I read Biodegradable Inorganic-organic Hybrids of Methacrylate Star Polymers for Bone Regeneration on EtoBox?
Biodegradable Inorganic-organic Hybrids of Methacrylate Star Polymers for Bone Regeneration by Justin J. Chung; Yuki Fujita; Siwei Li; Molly M. Stevens; Toshihiro Kasuga; Theoni K. Georgiou; Julian R. Jones is a Engineering article available to read on EtoBox.
What is Biodegradable Inorganic-organic Hybrids of Methacrylate Star Polymers for Bone Regeneration about?
## Statement of significance: Bioactive glasses can regenerate bone but are brittle. hybrids can overcome this problem as intimate interactions between glass and polymer creates synergetic properties. implants have previously been made with synthetic polymers that degrade by water, however, they degrade catastrophically, causing rapid loss of strength. polymers that degrade by biological agents may degrade at a more controlled rate, which should give time for tissue repair and transfer of load. previously, hybrids made with star shaped poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) (p(mma-co-tmspma)) showed enhanced properties. however, methacrylates are not bio-degradable. here, star shaped p(mma-co-tmspma) was synthesized with a core that can be cleaved by glutathione, a tripeptide. on exposure to glutathione, the hybrid degraded, producing products with molecular weights below the kidney filtration threshold.
Who reads Biodegradable Inorganic-organic Hybrids of Methacrylate Star Polymers for Bone Regeneration?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Justin J. Chung; Yuki Fujita; Siwei Li; Molly M. Stevens; Toshihiro Kasuga; Theoni K. Georgiou; Julian R. Jones
- Publisher
- Elsevier BV
- Published
- 2017
- Language
- EN
- Field
- Engineering (Physical Sciences)