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Effects of Human Low-Density Lipoproteins on Superoxide Production by Formyl-Methionyl-Leucyl-Phenylalanine Activated Polymorphonuclear Leukocytes by Christine Bonneau; Rémy Couderc; Michéle Tissot; Anne Athias; Monique Roch-Arveiller; Jean Paul Giroud is a Medicine article available to read on EtoBox.

What is Effects of Human Low-Density Lipoproteins on Superoxide Production by Formyl-Methionyl-Leucyl-Phenylalanine Activated Polymorphonuclear Leukocytes about?

Neutrophils play a major role in the host defence by producing reactive oxygen species. These products are liberated by activated cells and are known to cause endothelial cell injury and damage. The present study shows that low-density lipoproteins increase Superoxide anion production by twofold in polymorphonuclear leukocytes stimulated by formyl-Met-Leu-Phe in vitro. Moreover, LDL induced a large increase in phosphoinositides and cytosolic-free calcium. Data from experiments performed on neutrophils treated with pertussis toxin, staurosporine, propranolol or nifiumic acid suggest that modulation of phospholipase D and A 2 activities could be involved in the modification by LDL of leukocyte response to formyl-Met-Leu-Phe. LDL lipid moiety could play a key role in their action on polymorphonuclear functions because cholesterol was exchanged between lipoproteins and cells that can modify membrane fluidity and interact with the formyl-Met-Leu-Phe receptor.

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Author

Christine Bonneau; Rémy Couderc; Michéle Tissot; Anne Athias; Monique Roch-Arveiller; Jean Paul Giroud

Publisher

Walter de Gruyter GmbH

Published

1997

Language

EN

Field

Medicine (Health Sciences)