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Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine by Jean Bernard Lekana-Douki; Sylvatrie Danne Dinzouna Boutamba; Rafika Zatra; Sonya Estelle Zang Edou; Hervé Ekomy; Ulrick Bisvigou; Fousseyni S. Toure-Ndouo is a Medicine article available to read on EtoBox.

What is Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine about?

Despite global antimalarial measures, Plasmodium falciparum malaria remains a major public health problem. WHO has recommended the use of arteminisin-based combination therapy to limit the emergence of antimalarial drug resistance. However, ACT treatment failures have been linked to the selection of the wild types 86N genotype of P. falciparum multidrug resistance 1 (Pfmdr1) and the 76K genotype of P. falciparum chloroquine resistance (Pfcrt) genes. The aim of this study was to investigate the molecular impact of widespread implementation of artemether-lumefantrine and artesunatemefloquine on local parasite population in Franceville, Gabon. We analyzed 230 pediatric field isolates (96 from 2004 and 134 from 2009). Routine hematological parameters were collected. Pfmdr1 codons 86 and 1246 and Pfcrt codon 76 were genotyped using PCR-RFLP and the prevalence of the genotypes was compared. The children's mean age did not differ between 2004 and 2009 (respectively 31.8 (6-84) months vs 38.6 (6-84) months, p = 0.32), and neither did mean parasitemia [16,750 (1000-96,234) and 14,587 (1093-83,941) parasites/mL, respectively (p = 0.21)]. The mean hemoglobin level was higher in 2009 than in 2

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Author

Jean Bernard Lekana-Douki; Sylvatrie Danne Dinzouna Boutamba; Rafika Zatra; Sonya Estelle Zang Edou; Hervé Ekomy; Ulrick Bisvigou; Fousseyni S. Toure-Ndouo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)

Published

2011

Language

EN

Field

Medicine (Health Sciences)