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Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer by Rebecca A. Burrell; Nicolai Juul; Stephen R. Johnston; Jorge S. Reis-Filho; Zoltan Szallasi; Charles Swanton is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer about?

## Abstract Chromosomal instability (CIN) is a common cause of tumour heterogeneity and poor prognosis in solid tumours and describes cell–cell variation in chromosome structure or number across a tumour population. In this article we consider evidence suggesting that CIN may be targeted and may influence response to distinct chemotherapy regimens, using HER2‐positive breast cancer as an example. Pre‐clinical models have indicated a role for HER2 signalling in initiating CIN and defective cell‐cycle control, and evidence suggests that HER2‐targeting may attenuate this process. Anthracyclines and platinum agents may target tumours with distinct patterns of karyotypic complexity, whereas taxanes may have preferential activity in tumours with relative chromosomal stability. A greater understanding of karyotypic complexity and identification of methods to directly examine and target CIN may support novel strategies to improve outcome in cancer. J. Cell. Biochem. 111: 782–790, 2010. © 2010 Wiley‐Liss, Inc.

Who reads Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer?

Author

Rebecca A. Burrell; Nicolai Juul; Stephen R. Johnston; Jorge S. Reis-Filho; Zoltan Szallasi; Charles Swanton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)