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Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise by Rafael Ishihara; Marcelo Paes de Barros; Cristiano Mendes da Silva; Leandro da Silva Borges; Elaine Hatanaka; Rafael Herling Lambertucci is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise about?
We investigated the effects of melatonin on the onset and resolution of the oxidative stress in the cardiac muscle in melatonin-treated and nontreated rats subjected to an exhaustive exercise session. Forty male rats were divided into: melatonin-treated (20 mg/kg supplemented for 10 d) and control. On the 10th day, each group was subdivided according to euthanasia moments: control or melatonin-treated not exercised (C0h and M0h); immediately after the exercise (CIA and MIA); and 2 h after exercise (C2h and M2h). The heart of animals was removed and the levels of oxidative stress index (OSI) and the formation of thiobarbituric acid reactive substances (TBARS), protein carbonyl, and the activities of aconitase, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were evaluated. Total antioxidant status (TAS), total oxidant status (TOS), and the protein expression of CAT, GPx, and SOD was also measured. Our data revealed significant differences on: (i) OSI (p1⁄4.029), CAT activity (p1⁄4.016), CAT content (p<.001), GPx content (p1⁄4.014), reduced glutathione levels (p<.001), and aconitase activity (p<.001) for interaction of melatonin; (ii) GPx activity (p1⁄4.0
Who reads Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rafael Ishihara; Marcelo Paes de Barros; Cristiano Mendes da Silva; Leandro da Silva Borges; Elaine Hatanaka; Rafael Herling Lambertucci
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)