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Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease by Saradhadevi Varadharaj; Owen J. Kelly; Rami N. Khayat; Purnima S. Kumar; Naseer Ahmed; Jay L. Zweier is a Medicine article available to read on EtoBox.
What is Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease about?
In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to -glutathionylation of critical cysteine residues, resulting in superoxide free radical formation instead of the vasodilator molecule, nitric oxide. In addition, the redox sensitive cofactor tetrahydrobiopterin, BH, is also essential for eNOS coupling. Antioxidants, either individually or combined, can modulate eNOS uncoupling by scavenging free radicals or impairing specific radical generating pathways, thus preventing oxidative stress and ameliorating VED. Epidemiological evidence and dietary guidelines suggest that diets high in antioxidants, or antioxidant supplementation, could preserve vascular health and prevent cardiovascular diseases (CVDs). Therefore, the purpose of this review is to highlight the possible role of dietary antioxidants in regulating eNOS function and uncoupling which is critical for maintenance of vascular health with normal blood flow/circulation and prevention of VED. We hypothesize that
Who reads Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Saradhadevi Varadharaj; Owen J. Kelly; Rami N. Khayat; Purnima S. Kumar; Naseer Ahmed; Jay L. Zweier
- Publisher
- Frontiers Media SA
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)