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Differential regulation by stimulants of neocortical expression of mrt1 , arc , and homer1a mRNA in the rats treated with repeated methamphetamine by Ko Fujiyama; Yasushi Kajii; Shuichi Hiraoka; Toru Nishikawa is a Neuroscience article available to read on EtoBox.

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## Abstract The present work was conducted to obtain clues for the possible roles of a novel stimulant‐inducible gene __mrt1__ (methamphetamine‐responsive transcript 1) encoding a PDZ‐PX protein in stimulant‐induced behavioral sensitization. In the young adult rats, repeated daily treatment with methamphetamine (4 mg/kg, intraperitoneally, once a day) for 5 days caused an enhanced behavioral response to methamphetamine: behavioral sensitization. The 5‐day intermittent administration of MAP upregulated the basal expression of __mrt1__ transcripts and eliminated the increasing effects of a challenge dose of MAP (1.6 mg/kg, i.p.) or cocaine (30 mg/kg, i.p.) on __mrt1__ expression on day 14 of withdrawal in the neocortex that has been considered to be composed of a neuron circuit implicated in the sensitization phenomenon. In contrast, the basal expression of other stimulant‐inducible and plasticity‐related genes __arc__ and __homer1a__ and the ability of MAP or cocaine challenge to augment the amounts of their transcripts were not affected by the repeated MAP regimen in the cortical area. These findings suggest the differential regulation by stimulant of neocortical __mrt1, arc,__ and

Who reads Differential regulation by stimulants of neocortical expression of mrt1 , arc , and homer1a mRNA in the rats treated with repeated methamphetamine?

Author

Ko Fujiyama; Yasushi Kajii; Shuichi Hiraoka; Toru Nishikawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)