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Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents by Dongxu Yi; Yuhang Dong; Qinglin Wang; Juan Wu; Minghui Qi; Guobin Ren is a Chemical Engineering article available to read on EtoBox.

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The form II of Rotigotine (RTG), a dopamine agonist used to treat Parkinson's disease and Wills-Ekbom disease, is a stable crystal that is suitable for industrial production. In our study, we measured the solubility of RTG in ten solvents, including alcohols and esters, using UV spectrophotometry at temperatures ranging from 278.15 to 313.15 K and atmospheric pressure. Our results showed an increasing trend in solubility with temperature and an increase in carbon chain length of the solvents, except for 2-propanol and isopropyl acetate. By fitting six thermodynamic models to the solubility data, we found strong correlation. Simulation calculations indicated that HH and CH bonds are dominant among RTG molecules, and the solubility of RTG has a positive trend with the increase in viscosity and carbon chain length of the solvents.

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Author

Dongxu Yi; Yuhang Dong; Qinglin Wang; Juan Wu; Minghui Qi; Guobin Ren

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Chemical Engineering (Physical Sciences)