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What is Enantioselective Acyl-Trifluoromethylation about?

This article presents a novel method for the enantioselective acyl-trifluoromethylation of olefins using a new family of bulky chiral thiazolium carbene catalysts. The catalysts achieve high enantioselectivities and yields for the synthesis of β-trifluoromethylated α-chiral ketones, which are valuable in pharmaceuticals and agrochemicals. The study highlights the tunability of the chiral catalysts and their potential application in late-stage functionalizations of complex molecules.

Author

abchem786

Language

EN