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Can I read TAF15 amyloid filaments in frontotemporal lobar degeneration on EtoBox?
TAF15 amyloid filaments in frontotemporal lobar degeneration by Stephan Tetter; Diana Arseni; Alexey G. Murzin; Yazead Buhidma; Sew Y. Peak-Chew; Holly J. Garringer; Kathy L. Newell; Ruben Vidal; Liana G. Apostolova; Tammaryn Lashley; Bernardino Ghetti; Benjamin Ryskeldi-Falcon is a Physics and Astronomy article available to read on EtoBox.
What is TAF15 amyloid filaments in frontotemporal lobar degeneration about?
Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer’s disease, and is often also associated with motor disorders^1^. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins^2^. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes^3,4^. The presence of amyloid filaments and their identities and structures in the remaining approximately 10% of FTLD cases are unknown but are widely believed to be composed of the protein fused in sarcoma (FUS, also known as translocated in liposarcoma). As such, these cases are commonly referred to as FTLD–FUS. Here we used cryogenic electron microscopy (cryo-EM) to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with FTLD–FUS. Surprisingly, we found abundant amyloid filaments of the FUS homologue TATA-binding protein-associated factor 15 (TAF15, also known as TATA-binding protein-associated factor 2N) rather than of FUS it
Who reads TAF15 amyloid filaments in frontotemporal lobar degeneration?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Stephan Tetter; Diana Arseni; Alexey G. Murzin; Yazead Buhidma; Sew Y. Peak-Chew; Holly J. Garringer; Kathy L. Newell; Ruben Vidal; Liana G. Apostolova; Tammaryn Lashley; Bernardino Ghetti; Benjamin Ryskeldi-Falcon
- Publisher
- Nature Publishing Group UK
- Published
- 2023
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)