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Can I read Effect of Neoadjuvant Therapy on the Functional Outcome of Patients With Rectal Cancer: A Systematic Review and Meta-Analysis on EtoBox?
Effect of Neoadjuvant Therapy on the Functional Outcome of Patients With Rectal Cancer: A Systematic Review and Meta-Analysis by Xiangyuan Li; Rongrong Fu; Haixiang Ni; Nannan Du; Mengfei Wei; Mengting Zhang; Yetan Shi; Yujing He; Liwen Du is a Medicine article available to read on EtoBox.
What is Effect of Neoadjuvant Therapy on the Functional Outcome of Patients With Rectal Cancer: A Systematic Review and Meta-Analysis about?
## Aims: The impact of neoadjuvant therapy on the functional outcome of patients with resectable rectal cancer is still controversial. the aim of the present study was to explore the effects of neoadjuvant therapy on anorectal function (arf), urinary function and sexual function in relevant patients. ## Materials and methods: Pubmed, embase, web of science and the cochrane library were searched systematically. all english-language studies, published from january 2000 to july 2021, that explored the (postoperative) effects of neoadjuvant therapy versus upfront surgery on arf, urinary function and sexual function of patients were included (prospero 2021: crd42021281617). ## Results: The data in this study were derived from 37 articles based on 33 studies; in total, 17 917 patients were enrolled. the meta-analysis revealed that the incidence of anorectal dysfunction in the neoadjuvant therapy group was significantly higher than that in the group of upfront surgery, which was manifested by a higher incidence of major low anterior resection syndrome (odds ratio = 3.09, 95% confidence interval = 2.48, 3.84; p < 0.001), reduction of mean squeeze pressure and mean resting pressure, and oth
Who reads Effect of Neoadjuvant Therapy on the Functional Outcome of Patients With Rectal Cancer: A Systematic Review and Meta-Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Xiangyuan Li; Rongrong Fu; Haixiang Ni; Nannan Du; Mengfei Wei; Mengting Zhang; Yetan Shi; Yujing He; Liwen Du
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)