Can I read Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy on EtoBox?

Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy by Xing-Hua Liao; Nan Wang; Qing-Xi Liu; Tao Qin; Bo Cao; Dong-Sun Cao; Tong-Cun Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy about?

## Abstract Myocardin is a remarkably potent transcriptional coactivator expressed specifically in cardiac muscle lineages and smooth muscle cells during postnatal development. Myocardin shares homology with myocardin‐related transcription factor‐A (MRTF‐A), which are expressed in a broad range of embryonic and adult tissues. Our previous results show that myocardin induces cardiac hypertrophy. However, the effects of MRTF‐A in cardiac hypertrophy remain poorly understood. Our present work further demonstrates that myocardin plays an important role in inducing hypertrophy. At the same time, we find that overexpression of MRTF‐A in neonatal rat cardiomyocytes might induce cardiomyocyte hypertrophy. Furthermore, MRTF‐A expression is induced in phenylephrine, angiotensin‐II, and transforming growth factor‐β‐stimulated cardiac hypertrophy, whereas a dominant‐negative form of MRTF‐A or MRTF‐A siRNA strongly inhibited upregulation of hypertrophy genes in response to hypertrophic agonists in neonatal rat cardiomyocytes. Our studies indicate that besides myocardin, MRTF‐A might play an important role in cardiac hypertrophy. Our findings provide novel evidence for the future studies to expl

Who reads Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy?

Author

Xing-Hua Liao; Nan Wang; Qing-Xi Liu; Tao Qin; Bo Cao; Dong-Sun Cao; Tong-Cun Zhang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; Informa UK Limited (ISSN 1521-6543)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)