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Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing by Hoff, Jessica (author);Karl, Berit (author);Gerstmeier, Jana (author);Beekmann, Uwe (author);Schmölz, Lisa (author);Börner, Friedemann (author);Kralisch, Dana (author);Bauer, Michael (author);Werz, Oliver (author);Fischer, Dagmar (author);Lorkowski, Stefan (author);Press, Adrian T. (author) is a Materials Science article available to read on EtoBox.

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Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing wi

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Author

Hoff, Jessica (author);Karl, Berit (author);Gerstmeier, Jana (author);Beekmann, Uwe (author);Schmölz, Lisa (author);Börner, Friedemann (author);Kralisch, Dana (author);Bauer, Michael (author);Werz, Oliver (author);Fischer, Dagmar (author);Lorkowski, Stefan (author);Press, Adrian T. (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)