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Journal of Affective Disorders, 368 (2025) 711-719. doi:10.1016/j.jad.2024.09.110ABSTRACTKeywords:Background: Borderline personality disorder (BPD) and complex posttraumatic stress disorder (cPTSD) share Complex post-traumatic stress disorderclinical similarities, complicating diagnosis and treatment. Research on the neurobiology of BPD and monoBorderline personality disordertraumatic PTSD has shown that a prefrontal-limbic imbalance in emotional and reward processing is a hallmark Functional MRIof both disorders, but studies examining this network in cPTSD are lacking. Therefore, this study aimed to Reward processingdirectly compare neural processing of emotion and reward during decision making in cPTSD and BPD.Emotional processingMethods: Using functional magnetic resonance imaging, we measured neural activity in female patients (27 Desire reason dilemma taskpatients with cPTSD, 21 patients with BPD and 37 healthy controls) during a Desire-Reason Dilemma task featuring distracting fearful facial expressions.Results: We found no differences in neural activation when comparing cPTSD and BPD. However, when grouping patients based on symptom severity instead on diagnosis, we found t

Author

Christiane Rheude

Publisher

x

Published

2024

Language

EN