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Assessment of the association between cytomegalovirus DNAemia and subsequent acute graft‐versus‐host disease in allogeneic peripheral blood stem cell transplantation: A multicenter study from the Spanish hematopoietic transplantation and cell therapy group by Felipe Bueno; Carlos Solano; Lourdes Vázquez; Estela Giménez; Rafael de la Cámara; Eliseo Albert; Montserrat Rovira; Ildefonso Espigado; Carmen Martín Calvo; Javier López‐Jiménez; María Suárez‐Lledó; Anabella Chinea; Albert Esquirol; Ariadna Pérez; Aránzazu Bermúdez; Raquel Saldaña; Inmaculada Heras; Ana Julia González‐Huerta; Tamara Torrado; Montserrat Batlle; Santiago Jiménez; Carlos Vallejo; Pere Barba; María Ángeles Cuesta; Rafael Duarte; José Luis Piñana; David Navarro; Spanish Group of Hematopoietic Transplantation, Cell Therapy (GETH) is a Medicine article available to read on EtoBox.

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## Abstract The potential role of active CMV infection in promoting acute Graft‐versus‐Host Disease (aGvHD) in allogeneic hematopoietic stem cell transplantation (allo‐HSCT) remains a matter of debate. We further addressed this issue conducting a retrospective, observational, multicenter study of 632 patients subjected to allogeneic peripheral blood HSCT at 20 Spanish centers. Monitoring of CMV DNA load in plasma or whole blood was performed by real‐time PCR assays. Cumulative incidence of CMV DNAemia was 48.9% (95% CI, 45%‐52.9%), of any grade aGvHD, 45.6; 95% (CI, 41.3%‐50.1%), and of grade II‐IV aGvHD, 30.7 (95% CI, 24.9%‐36.4%). Overall, development of CMV DNAemia at any level resulted in an increased risk of subsequent all grade (HR, 1.38; 95% CI, 1.08 ‐ 1.76; P = .009) or grade II‐IV (HR, 1.58; 95% CI, 1.22 ‐ 2.06; P = .001) aGvHD. The increased risk of aGvHD linked to prior occurrence of CMV DNAemia was similar to the above when only clinically significant episodes were considered for the analyses (HR for all grade aGvHD, 1.48; 95% CI, 1.13 ‐ 1.91; P = .041, and HR for grade II‐IV aGvHD, 1.53; 95% CI. 1.13‐1.81; P = .04). The CMV DNA doubling time in blood was comparable ove

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Author

Felipe Bueno; Carlos Solano; Lourdes Vázquez; Estela Giménez; Rafael de la Cámara; Eliseo Albert; Montserrat Rovira; Ildefonso Espigado; Carmen Martín Calvo; Javier López‐Jiménez; María Suárez‐Lledó; Anabella Chinea; Albert Esquirol; Ariadna Pérez; Aránzazu Bermúdez; Raquel Saldaña; Inmaculada Heras; Ana Julia González‐Huerta; Tamara Torrado; Montserrat Batlle; Santiago Jiménez; Carlos Vallejo; Pere Barba; María Ángeles Cuesta; Rafael Duarte; José Luis Piñana; David Navarro; Spanish Group of Hematopoietic Transplantation, Cell Therapy (GETH)

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)