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The effectiveness and tolerability of anti‐seizure medication in alcohol withdrawal syndrome: a systematic review, meta‐analysis and GRADE of the evidence by Jou‐Yin Lai; Nicola Kalk; Emmert Roberts is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Aims Anti‐seizure medications (ASMs) have been used historically as treatment options in alcohol withdrawal syndrome (AWS). In the past 10 years, there have been no large‐scale meta‐analyses comparing ASMs with placebo or the current AWS treatment standard, benzodiazepines. We aimed to evaluate the efficacy and tolerability of ASMs in AWS. ## Methods Systematic review and meta‐analysis of randomised controlled trials (RCTs) via searching Medline, Embase and PsychINFO from database inception to March 2020 involving adults age >18 years with AWS. We included 24 RCTs reporting on a total of 2223 participants. Efficacy outcomes included the number of participants experiencing AWS related seizures or delirium, Clinical Institute Withdrawal Assessment for Alcohol–Revised (CIWA‐Ar) score reduction and rescue medication requirements. Tolerability outcomes included adverse event rate and dropout because of adverse events, alongside severe and life‐threatening adverse event rates. Quality was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE). ## Results There was no evidence of significant improvements in any efficacy outco

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Author

Jou‐Yin Lai; Nicola Kalk; Emmert Roberts

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)