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A third family of allelic hsd genes in Salmonella enterica: sequence comparisons with related proteins identify conserved regions implicated in restriction of DNA by Annette J. B. Titheradge; Diane Ternent; Noreen E. Murray is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A third family of allelic hsd genes in Salmonella enterica: sequence comparisons with related proteins identify conserved regions implicated in restriction of DNA about?

__Salmonella enterica__ serovar __blegdam__ has a restriction and modification system encoded by genes linked to __serB__. We have cloned these genes, putative alleles of the __hsd__ locus of __Escherichia coli__ K‐12, and confirmed by the sequence similarities of flanking DNA that the __hsd__ genes of __S. enterica__ serovar __blegdam__ have the same chromosomal location as those of __E. coli__ K‐12 and __Salmonella enterica__ serovar __typhimurium__ LT2. There is, however, no obvious similarity in their nucleotide sequences, and while the gene order in __S. enterica__ serovar __blegdam__ is __serB hsdM__, __S__ and __R__, that in __E. coli__ K‐12 and __S. enterica__ serovar __typhimurium__ LT2 is __serB hsdR__, __M__ and __S__. The __hsd__ genes of __S. enterica__ serovar __blegdam__ identify a third family of __serB__‐linked __hsd__ genes (type ID). The polypeptide sequence predicted from the three __hsd__ genes show some similarities (18–50% identity) with the polypeptides of known and putative type I restriction and modification systems; the highest levels of identity are with sequences of __Haemophilus influenzae__ Rd. The HsdM polypeptide has the motifs characteristic of ade

Who reads A third family of allelic hsd genes in Salmonella enterica: sequence comparisons with related proteins identify conserved regions implicated in restriction of DNA?

Author

Annette J. B. Titheradge; Diane Ternent; Noreen E. Murray

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)