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Can I read TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis on EtoBox?
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis by Lan Wang; Wenyu Zhao; Cong Xia; Shuaichen Ma; Zhongzheng Li; Ningdan Wang; Linke Ding; Yaxuan Wang; Lianhui Cheng; Huibing Liu; Juntang Yang; Yajun Li; Ivan Rosas; Guoying Yu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis about?
Idiopathic pulmonary fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology, described as the result of multiple cycles of epithelial cell injury and fibroblast activation. Despite this impressive increase in understanding, a therapy that reverses this form of fibrosis remains elusive. In our previous study, we found that miR-29b has a therapeutic effect on pulmonary fibrosis. However, its anti-fibrotic mechanism is not yet clear. Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency of TRIOBP increases resistance to lung fibrosis in vivo. TRIOBP knockdown inhibited the proliferation of epithelial cells and attenuated the activation of fibroblasts. In addition, deficiency of Trio Rho Guanine Nucleotide Exchange Factor (TRIO) in epithelial cells and fibroblasts decreases susceptibility to lung fibrosis. TRIOBP interacting with TRIO promoted abnormal epithelial–mesenchymal crosstalk and modulated the nucleocytoplasmic translocation of β-catenin. We concluded that the miR-29b‒TRIOBP–TRIO–β-catenin axis might be a key anti-fibrotic axis in IPF to regulate lung regeneration and fibrosis, w
Who reads TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lan Wang; Wenyu Zhao; Cong Xia; Shuaichen Ma; Zhongzheng Li; Ningdan Wang; Linke Ding; Yaxuan Wang; Lianhui Cheng; Huibing Liu; Juntang Yang; Yajun Li; Ivan Rosas; Guoying Yu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)