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Clinical Efficacy of First and Second Series of Peptide Receptor Radionuclide Therapy in Patients with Neuroendocrine Neoplasm: a Cohort Study by M. D. Zacho; P. Iversen; G. E. Villadsen; S. M. D. Baunwall; A. K. Arveschoug; H. Grønbaek; G. Dam is a Medicine article available to read on EtoBox.

What is Clinical Efficacy of First and Second Series of Peptide Receptor Radionuclide Therapy in Patients with Neuroendocrine Neoplasm: a Cohort Study about?

## Objectives: Peptide receptor radionuclide therapy (prrt) is an established treatment for metastatic neuroendocrine neoplasms (nen). however, only limited data exists for the effect of multiple series of prrt. the aim of this study was to investigate pfs and os innen patients treated with multiple series of prrt conforming to the enets treatment protocol. ## Methods: We included all patients with gastrointestinal (gi), pancreatic and bronchopulmonary (bp) nen treated with prrt from 2008 to 2018. we used kaplan-meier estimation to evaluate pfs and os with subgroup analysis of primary tumor, ki67-index, type of radioisotope and number of prrt series. ## Results: 133 patients (female/male 61/72) were included, median age 70 (interquartile range 64-76) years. gi-nen comprised 62%, pancreatic 23% and bp 11%. median ki67-index was 5%. after first prrtg1- and g2-tumors had pfs of 25 and 22 months, compared to 11 months in g3-nens ( < .05) and pfs was longer in g1/g2 gi-nens than bp-nen (30vs. 12 months, < .05). after retreatment with a second series of prrt, the overall pfs (g1-g3) was 19 months, with g1- and g2-tumors having the highest pfs of 19 and 22 months, respectively. overall,

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Author

M. D. Zacho; P. Iversen; G. E. Villadsen; S. M. D. Baunwall; A. K. Arveschoug; H. Grønbaek; G. Dam

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)