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Can I read Evaluation of in-situ gel-forming eye drop containing bacteriophage against Pseudomonas aeruginosa keratoconjunctivitis in vivo on EtoBox?
Evaluation of in-situ gel-forming eye drop containing bacteriophage against Pseudomonas aeruginosa keratoconjunctivitis in vivo by Golnar Rahimzadeh; Majid Saeedi; Ali Nokhodchi; Mahmood Moosazadeh; Maryam Ghasemi; Seyyed Sohrab Rostamkalaei; Parham Mortazavi; Mohammad Eghbali; Reza Pourbakhshian; Mohammad Sadegh Rezai; Ebrahim Nemati Hevelaee is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Evaluation of in-situ gel-forming eye drop containing bacteriophage against Pseudomonas aeruginosa keratoconjunctivitis in vivo about?
__**Introduction:**__ Eradication of __Pseudomonas aeruginosa__ has become increasingly difficult due to its remarkable capacity to resist antibiotics. Bacteriophages have been suggested as an alternative treatment for bacterial infections. __**Methods:** In-situ__ gel-forming eye drop containing phage against __P. aeruginosa__ keratoconjunctivitis was prepared. The Cystoviridae phage was formulated as __in-situ__ gel-forming formulation which is a solution formulation but turns into gel when it contacts the eye. Therapeutic effectiveness of the __in-situ__ gel forming formulation was evaluated by histological examination on day 12 post-infection. __**Results:**__ The viscosity of selected formulation increased when it was instilled into the eye. The histological results showed edema, abscesses, and destruction of the stromal structure of cornea in groups where no in-situ gel-forming formulation was used. In the group where in-situ gel forming formulation was used, re-epithelialization and normal corneal structure were observed. __**Conclusion:** In-situ__ gel-forming ophthalmic formulation containing phage can be effective in the treatment of __P. aeruginosa__ keratoconjunctivit
Who reads Evaluation of in-situ gel-forming eye drop containing bacteriophage against Pseudomonas aeruginosa keratoconjunctivitis in vivo?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Golnar Rahimzadeh; Majid Saeedi; Ali Nokhodchi; Mahmood Moosazadeh; Maryam Ghasemi; Seyyed Sohrab Rostamkalaei; Parham Mortazavi; Mohammad Eghbali; Reza Pourbakhshian; Mohammad Sadegh Rezai; Ebrahim Nemati Hevelaee
- Publisher
- Maad Rayan Publishing Company
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)